منابع مشابه
The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis
The AKT3 signalling pathway plays a critical role in melanoma formation and invasion and components of this signalling cascade are therefore attractive targets for the treatment of malignant melanoma. Recent evidence show that the embryonically important TBX3 transcription factor is upregulated in a subset of melanomas and plays a key role in promoting melanoma formation and invasion, in part b...
متن کاملThe T-Box factor TBX3 is important in S-phase and is regulated by c-Myc and cyclin A-CDK2.
The transcription factor, TBX3, is critical for the formation of, among other structures, the heart, limbs and mammary glands and haploinsufficiency of the human TBX3 gene result in ulnar-mammary syndrome which is characterized by hypoplasia of these structures. On the other hand, the overexpression of TBX3 is a feature of a wide range of cancers and it has been implicated in several aspects of...
متن کاملMurine T-box transcription
Cardiac development in mammals is guided by an ancient and conserved genetic program (Cripps and Olson, 2002; Harvey, 2002; Zaffran and Frasch, 2002). However, how the cardiac program unfolds, the specific relationships between patterning events and the transcription factor hierarchy, and how cardiomyocyte function impacts on heart form remain poorly understood. Of 18 T-box factor genes identif...
متن کاملT-box Community for Azc
In order to provide privacy for all the residents, individual rooms are especially important. According to the research, the average size for each individual is only 5m, the size is so limited for daily life, so how to reach the maximum use of the minimum space is discussed, different products of transformable beds, table and chairs were compared. Murphy bed, down folding table and free folding...
متن کاملTBX3 Is Overexpressed in Breast Cancer and Represses p14 by Interacting with Histone Deacetylases
TBX3 is a transcription factor of the T-box gene family. Mutations in the TBX3 gene can cause hypoplastic or absent mammary glands. Previous studies have shown that TBX3 might be associated with breast cancer. Here, we show that TBX3 is overexpressed in malignant cells of primary breast cancer tissues by immunohistochemistry. TBX3 interacts with histone deacetylases (HDAC) 1, 2, 3, and 5. TBX3 ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2013
ISSN: 1768-3262
DOI: 10.4267/2042/51044